Red Cloud, who also was known by the names of Two Arrows and Tall Hollow Horn, only married once. His wife was Pretty Owl, also known as Mary Good Road and Pretty Woman. They had five children:- Charge At (aka Watakpe), Tells Hill Red Cloud (aka Fannie Chase Alone), Jack Red Cloud, Louise Red Cloud and Julia Red Cloud (aka Wears War Bonnet).
Red Cloud lived until 1909 while Pretty Owl out lived her husband, dying in 1940.
His uncle, Chief Smoke (the brother of his mother, Walks As She Thinks) was the father of American Horse.